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系所主任

      director wu吳彰哲博士（Chang-Jer Wu, Ph.D.）

     職稱：特聘教授兼學程主任及院長

     學歷：國防醫學院博士

     專長：分生物、生物技術學、免疫學、病毒學、基因治療、腫瘤生物學

     辦公室電話：+886-2-2462-2192 # 5000、5137

  •      E-mail：cjwu@mail.ntou.edu.tw

 

研究著作：期刊論文1997-2022約73篇、專書1998-2020共11本 

期刊論文（近5年）

  1. Wang, H.*, Y. L. Chan, Y. H. Chiu, T. H. Wu, S. Hsia, and C. J. Wu*. Supplementation with fish oil and selenium protects lipolytic and thermogenic depletion of adipose in cachectic mice treated with an EGFR inhibitor. Cells. 13, 1485. 2024.
  2. Huang, T. H., B. H. Liu, C. H. Hsu, C. J. Wu, K. W. Liao, C. S. Lin*, and Y. L. Chan*. The synergistic effects of Corbicula fluminea and Sarcodia montagneana on alleviating systemic inflammation and osteoarthritis progression. Antioxidants. 12, 2068. 2023. (SCI, Impact Factor: 7.0, 13/142, FOOD SCIENCE & TECHNOLOGY)
  3. Wang, X., H. Zheng, Y. Wu, H. Sun, A. Chang, Z. Zhou, W. Bao, C. Li, D. Zhang, C. J. Wu, A. Zhu, and H. Zhu*. Cyclodextrin-modified amphiphilic microgel with bifunctional domains for infected wound healing via photothermal antibacterial therapy and nitric oxide release. ACS Applied Materials & Interfaces. 15, 27548-27559. 2023. (SCI, Impact Factor: 9.15, 55/344, MATERIALS SCIENCE, MULTIDISCIPLINARY)
  4. Li, L., Z. Xu, R. Cao, J. Li, C. J. Wu, Y. Wang, and H. Zhu*. Effects of hydroxyl group in cyclo(Pro-Tyr)-like cyclic dipeptides on their anti-QS activity and self-assembly. iScience. 26, 107048. 2023. (SCI, Impact Factor: 5.8, 15/73, MULTIDISCIPLINARY SCIENCES)
  5. Zheng, Y., S. Chen, K. Mao, X. Zhu, M. Jiang, C. J. Wu, J. Lu, and H. Zhu*. de Novo-designed antimicrobial peptides with broad-spectrum antimicrobial potency and rapid wound disinfection. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 667, 131355, 2023. (SCI, Impact Factor: 5.2, 58/161, CHEMISTRY, PHYSICAL)
  6. Lin, H. Y., K. L. Luo, J. Y. Mao, C. J. Lin, C. Y. Wang, L. Panny, S. Y. Chen, S. C. Lin*, C. C. Huang, S. G. Harroun, R. Y. L. Wang, and C. J. Wu*. In situ derived sulfated/sulfonated carbon nanogels with multi-protective effects against influenza a virus. Chemical Engineering Journal. 458, 141429, 2023. (SCI, Impact Factor: 15.1, 5/142, ENGINEERING, CHEMICAL)
  7. Zheng, Y., K. Mao, S. Chen, X. Zhu, M. Jiang, C. J. Wu, and H. Zhu*. Identification of heterochirality-mediated stereochemical interactions in peptide architectures. Colloids and Surfaces B: Biointerfaces. 224, 113200, 2023. (SCI, Impact Factor: 5.8, 9/70, BIOPHYSICS)
  8. Chang, A., Z. Ye, Z. Ye, J. Deng, J. Lin, C. J. Wu, and H. Zhu*. Citric acid crosslinked sphingan WL gum hydrogel films supported ciprofloxacin for potential wound dressing application. Carbohydrate Polymers. 622, 119520, 2022. (SCI, Impact Factor: 11.2, 2/52, CHEMISTRY, ORGANIC)
  9. Lin, H. Y., Y. T. Zeng, C. J. Lin, S. G. Harroun, A. Anand, L. Chang, C. J. Wu*, H. J. Lin, and C. C. Huang*. Partial carbonization of quercetin boost the antiviral activity against H1N1 influenza A virus. Journal of Colloid and Interface Science. 622, 481-493, 2022. (SCI, Impact Factor: 9.9, 29/161, CHEMISTRY, PHYSICAL)
  10. Wang, Y., L. Pan, L. Li, R. Cao, Q. Zheng, Z. Xu, C. J. Wu, and H. Zhu*. Glycosylation increases the anti-QS as well as anti-biofilm and anti-adhesion ability of the cyclo (L-Trp-L-Ser) against Pseudomonas aeruginosa. European Journal of Medicinal Chemistry. 238, 114457, 2022. (SCI, Impact Factor: 6.7, 7/60, CHEMISTRY, MEDICINAL)
  11. Feria, D. N., F. H. Hsu, Y. C. Chan, B. R. Chen, C. J. Wu*, and T. Y. Lin*. The dual-detection mode and improved photoresponse of IGZO-based photodetectors by interfacing with water-soluble biomaterials. Nanotechnology. 33, 245203, 2022. (SCI, Impact Factor: 3.5, 170/344, MATERIALS SCIENCE, MULTIDISCIPLINARY)
  12. Chen, B. R., W. M. Li, T. L. Li, Y. L. Chan*, and C. J. Wu*. Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori. Scientific reports. 33, 24, 2022. (SCI, Impact Factor: 4.6, 22/73, MULTIDISCIPLINARY SCIENCES)
  13. Chen, B. R., K. T. Hsu, T. L. Li, Y. L. Chan*, and C. J. Wu*. Topical application of fucoidan derived from Cladosiphon okamuranus alleviates atopic dermatitis symptoms through immunomodulation. International Immunopharmacology. 2021, 108362, 2021. doi: 10.1016/j.intimp.2021.108362. (SCI, Impact Factor: 5.6, 44/278, PHARMACOLOGY & PHARMACY)
  14. Chen, B. R., K. T. Hsu, W. H. Hsu, B. H. Lee, T. L. Li, Y. L. Chan*, and C. J. Wu*. Immunomodulation and mechanisms of fucoidan from Cladosiphon okamuranus ameliorates atopic dermatitis symptoms. International Journal of Biological Macromolecules. 189, 537-543, 2021. (SCI, Impact Factor: 8.2, 5/86, POLYMER SCIENCE)
  15. Yang, C. C., C. J. Wu, C. Y. Chien, and C. T. Chien*. Green tea polyphenol catechins inhibit coronavirus replication and potentiate the adaptive immunity and autophagy-dependent protective mechanism to improve acute lung injury in mice. Antioxidants. 10, 928, 2021. (SCI, Impact Factor: 7.0, 13/142, FOOD SCIENCE & TECHNOLOGY)
  16. Wang, H.*, S. Hsia, T. H. Wu, and C. J. Wu*. Fish oil, Se yeast, and micronutrient-enriched nutrition as adjuvant treatment during target therapy in a murine model of lung cancer. Marine Drugs. 19, 262, 2021. (SCI, Impact Factor: 5.4, 50/278, PHARMACOLOGY & PHARMACY)
  17. Lin, K. H., S. Y. Lyu, H. W. Yeh, Y. S. Li, N. S. Hsu, C. M. Huang, Y. L. Wang, H. W. Shih, Z. C. Wang, C. J. Wu, and T. L. Li*. Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity. Protein Science. 29, 1655-1666. 2020. (SCI, Impact Factor: 8.0, 36/285, BIOCHEMISTRY & MOLECULAR BIOLOGY)
  18. Liu, Y. M., T. H. Wu, Y. H. Chiu, H. Wang, T. L. Li, S. Hsia, Y. L. Chan*, and C. J. Wu*. Positive effects of preventive nutrition supplement on anticancer radiotherapy in lung cancer bearing mice. Cancers. 12, E2445, 2020. (SCI, Impact Factor: 5.2, 72/241, ONCOLOGY)
  19. Adhikari, K., I W. Lo, C. L. Chen, Y. L. Wang, K. H. Lin, S. MalekZadeh, R. Rattinam, Y. S. Li, C. J. Wu, and T. L. Li*. Chemoenzymatic synthesis and biological evaluation for bioactive molecules derived from bacterial benzoyl coenzyme a ligase and plant type III polyketide synthase. Biomolecules. 10, 738, 2020. (SCI, Impact Factor: 5.5, 70/285, BIOCHEMISTRY & MOLECULAR BIOLOGY)
  20. Zhong, R., X. Wan, D. Wang, C. Zhao*, D. Liu, L. Gao, M. Wang, C. J. Wu, S. M. Nabavid, M. Daglia, E. Capanoglu, J. Xiao*, and H. Cao*. Polysaccharides from marine Enteromorpha: structure and function. Trends in Food Science & Technology. 99, 11-20, 2020. (SCI, Impact Factor: 15.3, 2/142, FOOD SCIENCE & TECHNOLOGY)
  21. Wu, Y., H. Jiang, J. S. Lin, J. Liu, C. J. Wu*, and R. Xu*. Antioxidant, hypolipidemic and hepatic protective activities of polysaccharides from Phascolosoma esculenta. Marine Drugs. 18, 158, 2020. (SCI, Impact Factor: 5.4, 50/278, PHARMACOLOGY & PHARMACY)
  22. Wu, T. H., K. Y. Yeh, C. H. Wang, H. Wang, T. L. Li, Y. L. Chan*, and C. J. Wu*. The combination of Astragalus membranaceus and Angelica sinensis inhibits lung cancer and cachexia through its immunomodulatory function. Journal of Oncology. 2019, 9206951, 2019. doi: 10.1155/2019/9206951. (SCI, Impact Factor: 4.501, 113/245, ONCOLOGY)
  23. Shi, X., C. Xu, C. J. Wu, X. Wu, B. Zhang, X. Tang, L. Luo, and Y. H. Chen. A flavone C-Glycoside from Styela plicata. Biochemical Systematics and Ecology. 2019, 103924, 2019. doi: 10.1016/j.bse.2019.103924. (SCI, Impact Factor: 1.6, 125/171, ECOLOGY)
  24. Lyu, S. Y., K. H. Lin, H. W. Yeh, Y. S. Li, C. M. Huang, Y. L. Wang, H. W. Shih, N. S. Hsu, C. J. Wu, and T. L. Li*. The flavin mononucleotide cofactor in α-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallographica. Section D, Structural Biology. 75, 918-929, 2019. (SCI, Impact Factor: 2.2, 11/26, CRYSTALLOGRAPHY)
  25. Chen, Y. H., P. Chen, Y. Wang, C. H. Yang, X. Wu, C. J. Wu, L. Luo, Q. Wang, C. Niu, and J. Y. Yao. Structural characterization and anti-inflammatory activity evaluation of chemical constituents in the extract of Trifolium repens L. Journal of Food Biochemistry. 43, e12981, 2019. doi: 10.1111/jfbc.12981. (SCI, Impact Factor: 4.0, 48/142, FOOD SCIENCE & TECHNOLOGY)
  26. Liu, Y. M., Y. L. Chan, T. H. Wu, T. L. Li, S. Hsia, Y. H. Chiu*, and C. J. Wu*. Antitumor, inhibition of metastasis and radiosensitizing effects of total nutrition formula on Lewis tumor-bearing mice. Nutrients. 11, 1944, 2019. doi: 10.3390/nu11081944. (SCI, Impact Factor: 5.9, 17/88, NUTRITION & DIETETICS)
  27. Yeh, H. W., K. H. Lin, S. Y. Lyu, Y. S. Li, C. M. Huang, Y. L. Wang, H. W. Shih, N. S. Hsu, C. J. Wu, and T. L. Li*. Biochemical and structural explorations of α-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction. Acta Crystallographica. Section D, Structural Biology. 75, 733-742, 2019. (SCI, Impact Factor: 2.2, 11/26, CRYSTALLOGRAPHY)
  28. Huang, T. H., T. H. Wu, Y. H. Guo, T. L. Li, Y. L. Chan*, and C. J. Wu*. The concurrent treatment of Scutellaria baicalensis Georgi enhances the therapeutic efficacy of cisplatin but also attenuates chemotherapy-induced cachexia and acute kidney injury. Journal of Ethnopharmacology. 243, 112075, 2019. doi: 10.1016/j.jep.2019.112075. (SCI, Impact Factor: 5.4, 29/239, PLANT SCIENCES)
  29. Zhuang, L., B. Lin, L. Xu, G. Li, C. J. Wu, and L. Luo*. Erythrobacter spongiae sp. nov., isolated from marine sponge. International Journal of Systematic and Evolutionary Microbiology. 69, 1111-1116, 2019. (SCI, Impact Factor: 2.689, 106/136, MICROBIOLOGY)
  30. Huang, C. M., S. Y. Lyu, K. H. Lin, C. L. Chen, M. H. Chen, H. W. Shih, N. S. Hsu, I. W. Lo, Y. L. Wang, Y. S. Li, C. J. Wu, and T. L. Li*. Teicoplanin reprogrammed with the N-acyl-Glc pharmacophore at the penultimate residue of aglycone acquires broad-spectrum antimicrobial activities effectively killing Gram-(+/-) pathogens. ACS Infectious Disease. 5, 430-442, 2019. (SCI, Impact Factor: 5.3, 15/60, CHEMISTRY, MEDICINAL)
  31. Cui, P., W. Shao, C. Huang, C. J. Wu, B. Jiang, and D. Lin*. Metabolic derangements of skeletal muscle from a murine model of glioma cachexia. Skeletal Muscle. 9, 3, 2019. (SCI, Impact Factor: 4.9, 80/191, CELL BIOLOGY)

詳細資訊：實驗室

歷屆主任

 許濤博士（Todd Hsu, Ph.D.）2023.08.01-2024.07.31

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