Jump to the main content block
  1. Home
  2. Faculty
  3. Professors
  4. Dr. Shih-Chao Lin

Dr. Shih-Chao Lin

sc   🎓   Ph.D. in Medical Biotechnology, National Chung Hsing University

   📞　02-24622192 ext. 5804            📧　 sclin@mail.ntou.edu.tw

   📖　Research Interests: Efficacy research and development of natural compounds, microbial pathogenic mechanism,

                                           animal models of infectious diseases, nano drug application

  LAB: MAF 304 Antiviral Lab

Publications:

  1. Lehman CW, Kehn-Hall K, Aggarwal M, Bracci NR, Pan HC, Panny L, Lamb RA, Lin SC (2021). Resveratrol Inhibits Venezuelan Equine Encephalitis Virus Infection by Interfering with the AKT/GSK Pathway. Plants, 10(2), 346.

  2. Chiang CC, Li YR, Lai KH, Cheng W, Lin SC, Wang YH, Chen PJ, Yang SH, Hwang TL, Lin CC (2020). Aqueous Extract of Kan-Lu-Hsiao-Tu-Tan Ameliorates Collagen-Induced Arthritis in Mice by Inhibiting Oxidative Stress and Inflammatory Responses. Life, 10(12), 313.

  3. Bracci N, Pan H, Lehman C, Kehn-Hall K, Lin SC (2020). Improved plaque assay for human coronaviruses 229E and OC43. PeerJ 8:e10639.

  4. Chiang CC, Li YR, Lai KH, Cheng WJ, Lin SC, Wang YH, Chen PJ, Yang SH, Hwang TL, Lin CC (2020). Aqueous extract of Kan-Lu-Hsiao-Tu-Tan ameliorates collagen-induced arthritis in mice by regulating immune and inflammatory responses. Life. 10(12), 313.

  5. Lin SC*, Lin CC*, Li S, Lin WY, Lehman CW, Bracci NR, Tsai SW (2020). Alleviation of Collagen-Induced Arthritis by Crotonoside through Modulation of Dendritic Cell Differentiation and Activation. Plants. 9(11):1535.

  6. Chen HL, Gong JY, Lin SC, Li S, Chiang YC, Hung JH, Yen CC, Lin CC (2020). Effects of Sclareol Against Small Cell Lung Carcinoma and the Related Mechanism: In Vitro and In Vivo Studies. Anticancer Res. 40(9):4947-4960.

  7. Wu CS, Lin SC, Li S, Chiang YC, Bracci N, Lehman CW, Tang KT, Lin CC (2020). Phloretin Alleviates Dinitrochlorobenzene-Induced Dermatitis in BALB/c Mice. International Journal of Immunopathology and Pharmacology. 34: 1–14

  8. Lin, SM*, Lin, SC*, Hsu, JN*, Chang, CK*, Chien, CM, Wang, YS, Wu, HY, Jeng, US, Kehn-Hall, K, & Hou, MH. (2020). Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design. Journal of Medicinal Chemistry. 63, 6, 3131-3141 *co-first author

  9. Carey, BD, Akhrymuk, I, Dahal, B, Pinkham, CL, Bracci, N, Finstuen-Magro, S, Lin, SC, Lehman, CW, Sokoloski, KJ, & Kehn-Hall, K. (2020). Protein Kinase C subtype δ interacts with Venezuelan equine encephalitis virus capsid 2 protein and regulates viral RNA binding through modulation of capsid phosphorylation. PLoS Pathogens. 16(3): e1008282.

  10. Akhrymuk, I*, Lin, SC*, Sun, M, Patnaik, A, Altamura, L, Lepene, B, van Hoek, M, & Kehn-Hall, K (2020). Magnetic NT Particles Preserve the Stability of Venezuelan Equine Encephalitis Virus in Blood for Laboratory Detection. Frontiers in Veterinary Science. 6:509 *co-first author

  11. Lin, SC, Carey, B, Callahan, V, Lee, JH, Bracci, N, Patnaik, A, Smith, AK, Narayanan, A, Lepene, B, & Kehn-Hall, K. (2020). Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine. PLoS One. 15(1):e0227058

  12. Dahal, B, Lin, SC, Carey, BD, Jacobs, JL, Dinman, JD, van Hoek, ML, Adams, AA, & Kehn-Hall, K. (2020). EGR1 upregulation following Venezuelan equine encephalitis virus infection is regulated by ERK and PERK pathways contributing to cell death. Virology. 539:121-128

  13. Chung, TW, Lin, CC, Lin, SC, Chan, HL, & Yang, CC. (2019). Antitumor effect of kurarinone and underlying mechanism in small cell lung carcinoma cells. OncoTargets and Therapy. 2019:12:6119-6131.

  14. Tsai, SW, Lin, CC, Lin, SC, Wang, SP, & Yang, DH. (2019). Isorhamnetin ameliorates inflammatory responses and articular cartilage damage in the rats of monosodium iodoacetate-induced osteoarthritis. Immunopharmacology and Immunotoxicology. 25;:1-9

  15. Chuang, CH, Cheng, YC, Lin, SC, Lehman, CW, Wang, SP, Chen, DY, Tsai, SW, & Lin, CC. (2019). Atractylodin suppresses dendritic cell maturation and ameliorates collagen-induced arthritis in a mouse model. Journal of Agricultural and Food Chemistry. 67:6773-6784

  16. Tan, KT, Lin, MX, Lin, SC, Tung, YT, Lin, SH, & Lin, CC. (2019). Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma. Anti-cancer Drugs. 30:485-494.

  17. Lin, SC, Chen, MC, Liu, S, Callahan, VM, Bracci, NR, Woodson, CM, Dahal, B, de la Fuente, C, Lin, CC, Wang, TT, & Kehn-Hall, K. (2019). Phloretin Inhibits Zika Virus Infection by Interfering with the Cellular Glucose Utilization. International Journal of Antimicrobial Agent. 54:80-84

  18. Wu, PC, Chuo, WH, Lin, SC, Lehman, CW, Lien, CZ, Wu, CS, & Lin, CC. (2019). Sclareol attenuates the development of atopic dermatitis induced by 2,4-dinitrochlorobenzene in mice. Immunopharmacology and Immunotoxicology. 1:1-8.

  19. Lundberg, L, Fontenot, J, Lin, SC, Pinkham, C, Carey, BD, Campbell, CE, & Kehn-Hall, K (2018). Venezuelan Equine Encephalitis Virus Capsid Implicated in Infection-Induced Cell Cycle Delay in vitro. Frontiers in Microbiology. 9:3126.

  20. Lin YC, Su JH, Lin SC, Chang CC, Hsia TC, Tung YT, & Lin CC (2018). A Soft Coral-Derived Compound, 11-Dehydrosinulariolide, Induces G2/M Cell Cycle Arrest and Apoptosis in Small Cell Lung Cancer. Marine Drugs. 16:479.

  21. Lin, SC, Lien, CZ, & Lin, CC. (2018). Potential of Carcinogenesis Induced by John-Cunningham Virus and Crude-Oil Extracts. International Archive of Medical Microbiology. 1:003.

  22. Lundberg, L, Brahms, A, Hooper, I, Carey, B, Lin, SC, Dahal, B, Narayanan, A, & Kehn-Hall, K. (2018). Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses. Antiviral Research. 157:57-67

  23. Tsai, SW, Hsieh, MC, Li S, Lin, SC, Wang, SP, Lehman, CW, Lien, CZ, & Lin, CC. (2018). Therapeutic Potential of Sclareol in Experimental Models of Rheumatoid Arthritis. International Journal of Molecular Sciences. 19:1351.

  24. Bell, TM, Espina, V, Lundberg, L, Pinkham, C, Brahms, A, Carey, BD, Lin, SC, Dahal, B, Woodson, C, de la Fuente, C, Liotta, LA, Bailey, CL, & Kehn-Hall, K. (2018). Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication. Viruses. 10:191.

  25. Shechter, S, Thomas, DR, Lundberg, L, Pinkham, C, Lin, SC, Wagstaff, KM, Debono, A, Kehn-Hall, K, & Jans, DA. (2017). Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design. Scientific Report. 7:17705

  26. Chung, TW, Li, YR, Huang, WY, Su, JH, Chan, HL, Lin, SH, Liu, CS, Lin, SC, Lin, CC, & Lin, CH. (2017). Sinulariolide suppresses LPS‑induced phenotypic and functional maturation of dendritic cells. Molecular Medicine Reports. 16:6992-7000.

  27. Bell, TM, Espina, V, Senina, S, Woodson, C, Brahms, A, Carey, B, Lin, SC, Lundberg, L, Pinkham, C, Baer, A, Mueller, C, Chlipala, EA, Sharman, F, de la Fuente, C, Liotta, L, & Kehn-Hall, K. (2017). Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis. Antiviral Research 143:162-175.

  28. Lin, SC, Chen, MC, Li, S, Lin, CC, & Wang, TT. (2017). Antiviral activity of nobiletin against chikungunya virus in vitro. Antiviral Therapy. 22:689-697.

  29. Lin, SC, Kappes, MA, Chen, MC, Lin, CC, & Wang, TT. (2017). Distinct susceptibility and applicability of MDCK derivatives for influenza virus research. PLoS One. 12:e0172299.

  30. Lin, SC, Ho, CT, Chuo, WH, Li, S, & Lin, CC. (2017). Effective inhibition of MERS-CoV infection by resveratrol. BMC Infectious Diseases. 17:144.

  31. Chung, TW, Lin, SC, Su, JH, Chen, YK, Lin, CC, & Chan, HL. (2017). Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells. BMC Complementary and Alternative Medicine 17:62.

  32. Wang, SP, Lin, SC, Li, S, Chao, YH, Hwang, GY, & Lin, CC. (2016) Potent Anti-arthritic Properties of Phloretin in Murine Collagen-induced Arthritis. Evidence-Based Complement Alternative Medicine. 2016: 9831263.

  33. Chen, MC, Lin, CF, Lei, HY, Lin, SC, Liu, HS, Yeh, TM, Anderson, R., & Lin, YS. (2009). The role of dengue virus nonstructural protein 1 (NS1) C-terminal region in anti-NS1-mediated platelet dysfunction. Journal of Immunology. 183(3):1797-803.

  34. Lin, CF, Wan, SW, Chen, MC, Lin, SC, Cheng, CC, Chiu, SC, Hsiao, YL, Lei, HY, Liu HS, Yeh, TM, & Lin, YS. (2008). Liver injury caused by antibodies against dengue virus nonstructural protein 1 in a murine model. Laboratory Investigation. 88(10):1079-89.

  35. Chen, CS*, Yao, YC*, Lin, SC*, Lee, YP, Wang, YF, Wang, JR, Liu, CC, Lei, HY, & Yu, CK. (2007) Retrograde axonal transport: a major transmission route of enterovirus 71 in mice. Journal of Virology. 81(17):8996-9003. *co-first author

研討會論文：

  1. Lin SC, Akhrymuk I, Patnaik A, Bertheir E, Lepene B, van Hoek M, Kehn-Hall K. Innovative Magnetic Nanoparticles Preserve the Stability of Venezuelan Equine Encephalitis Virus in Blood for Laboratory Detection. 2019 68th American Society of Tropical Medicine & Hygiene.

  2. Lin SC, Callahan V, Lundberg L, Lehman C, Kehn-Hall K. Equine Encephalitis Virus Infection by Interfering GSK-3 Pathway. 2018 31st American Society of Virology annual meeting

  3. Lin SC, Chen MC, Liu S, Bracci N, Woodson C, de la Fuente C, Lin CC, Wang TT, Kehn- Hall K. Phloretin inhibits Zika virus infection by interfering with cellular glucose utilization. 2017 Cell Symposium: Emerging and Re-emerging Viruses

  4. Lin SC, Chen MC, Nichols G, Voss T. Dengue: Influenza Co-infection: Modeling virus- virus interactions in vitro and in vivo. 2015 64th Annual meeting of American Society Tropical Medicine & Hygiene

  5. Voss T, Naveen S, Nichols G, Chen MC, Lin SC, Manukian G. Modeling Influenza Clinical Correlates in Ferrets: Identifying New Therapeutic Targets and Validating Current Approaches to Treat or Prevent Influenza. 2014 3rd Annual Influenza Research and Development Conference

Login Success